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funding

NATIONAL

 

NAME Chilean government funding agency FONDECYT
TITLE Defining the role of ER stress signaling in C9orf7-mediated ALS
ROLE Principal Investigator
ID 11180186. 2018-2021

 

NAME Chilean government, Millennium Scientific Initiative (Program grant)
TITLE Biomedical Neuroscience Institute (BNI)
ROLE Director
ID P09-015-F 2011-2021

 

NAME FONDAP (Program grant)
TITLE FONDAP Geroscience Center for Brain Health and Metabolism
ROLE Associate Investigator
ID 15150012 2015-2020

 

NAME CONICYT-Cooperation grant Chile-Brasil, Joint Call CNPq/ CONICYT
TITLE Disrupted proteostasis as a shared mechanism of cognitive decline in normal aging and Alzheimer´s disease
ROLE Principal investigator
ID 441921/2016­7 2017-2018

 

NAME Chilean government funding agency FONDEF
TITLE UPRplus: A novel gene therapy to treat Parkinson´s disease
ROLE Principal Investigator
ID D11I1007 2016-2019 (second period)

 

NAME CELLUS-BNI
TITLE Multineage-differentiating stress enduring stem cells derived from adipose tissue (Muse-AT)
ROLE Principal Investigator
ID 2017-2018

 

NAME Chilean government funding agency FONDEF
TITLE Proteostaser-1: a gene therapy to reduce neurodegeneration and improve cognitive function in Alzheimers disease
ROLE Principal Investigator
ID ID16I10223 2016-2018

 

NAME ECOS CONICYT Cooperation grant Chile-France
TITLE Novel Roles of the unfolded protein response (UPR) in cancer
ROLE Principal Investigator
ID ECOS170032. 2018-2020

 

 

NATIONAL – STAFF SCIENTISTS

 

NAME Chilean government funding agency FONDECYT INICIACION
TITLE Defining the role of IRE1 signaling in Cancer invasion and metastasis
ROLE Hery Urra, Principal Investigator 
ID 11180825. 2018-2021

 

NAME CONICYT-USA cooperation grant
TITLE Investigación traslacional en enfermedades neurodegenerativas y envejecimiento: estudio de factores de riesgo y biomarcadores inflamatorios
ROLE Claudia Durán-Aniotz, Principal Investigator
ID REDI170583

 

NAME Chilean government funding agency FONDECYT INICIACION
TITLE Targeting the UPR stress sensor IRE1 to treat Alzheimer’s disease
ROLE Claudia Durán-Aniotz, Principal Investigator
ID 111160760. 2016-2019

 

 

 

INTERNATIONAL

 

NAME The Michael J. Fox Foundation for Parkinson’s Research, USA?.TITLE: Gene therapy to restore ER proteostasis imbalance in Parkinson disease
TITLE Gene therapy to restore ER proteostasis imbalance in Parkinson disease
ROLE Principal Investigator
ID 12473, Target Validation grant (2017-2019)

 

NAME Office of Naval Research- Global (ONR-G)
TITLE A novel function of the Unfolded Protein Response (UPR) in learning and memory
ROLE Principal Investigator
ID N62909-16-1-2003 (2015-2017)

 

NAME U.S. Air Force Office of Scientific Research
TITLE Neuromorphic Inspired Science to Maximize Big Data Dynamic Problem Solving for Future intelligence, Surveillance, and Reconnaissance Operations
ROLE Principal Investigator
ID FA9550-16-1-0384 (2016-2017)

 

 

NAME Muscular Dystrophy Association, USA
TITLE Targeting the endoplasmic reticulum (ER) stress sensor IRE1 to treat SOD1-mediated ALS
ROLE Principal Investigator
ID 382453 (2016-2019)

 

NAME CDMRP ALS Research Program (ALSRP) Therapeutic Idea Award, USA
TITLE Targeting the ER Stress Sensor IRE1 to Treat ALS in SOD1 and TDP43 pathogenesis
ROLE Principal Investigator
ID AL150111 (2016-2017)

 

NAME European Commission R&D, MSCA-RISE 2016
TITLE Interfere to Suppress or Promote IRE1 (INSPIRED) RISE Program
ROLE Principal Investigator
ID 734749 (2016-2021)

 

NAME Seed Money Grant, Leading House for the Latin American Region, Switzerland
TITLE ER stress in post-traumatic distress order
ROLE Co-Principal Investigator
ID 2018

 

 

 

INTERNATIONAL – STAFF SCIENTISTS

 

NAME  Alzheimer’s Association Research Grant (AARG), USA
TITLE Targeting the UPR stress sensor IRE1 to treat Alzheimer’s disease
ROLE Claudia Durán-Aniotz, Principal Investigator
ID 2018-AARG-591107

 

 

POSTDOC FELLOW

 

NAME Chilean Government Funding agency FONDECYT
TITLE Identification of Chilean bioactive compounds from Ugni molinae to reduce abnormal aggregation in models of neurodegenerative diseases
ROLE Patrocinante
PI Alexis Rivas Ahumada
ID FONDECYT 3170695

 

 

NAME Chilean Government Funding agency FONDECYT
TITLE Defining the Contribution of ERp57 mutants to the Pathogenesis of Amyotrophic Lateral Sclerosis
ROLE Principal Investigator
PI Danilo Bilches Medinas
ID 11150579 (2015-2018)

 

NAME Chilean Government Funding agency FONDECYT
TITLE Role of ER stress on the cell autonomous or non-autonomous effect trigerred by Wallerian degeneration
ROLE Collaborator as Supervisor
PI Gabriela Martinez
ID FONDECYT 3150637

 

NAME Chilean Government Funding agency FONDECYT
TITLE Defining the contribution of the UPR stress sensor IRE1 in tumor and stromal cells to the development of brain cancer
ROLE Collaborator as Supervisor
PI Hery Urra Zúñiga (Co-advisor Andres Couve)
ID FONDECYT 3160461 (2016-2018)

NATIONAL

 

NAME Chilean government funding agency FONDECYT
TITLE The UPRosome: novel regulatory checkpoints and physiological outputs
ROLE Principal investigator
ID 1140549 (2014-2018). Project ranked number one in the study section

 

NAME Fundacion COPEC-UC
TITLE Identification of neuroprotective compounds from chilean endogenous plants
ROLE Principal investigator
ID 2013.R.40 (2014-2016)

 

NAME CONICYT-Cooperation grant Chile-EEUU
TITLE Gene therapy strategy to target the unfolded protein response in ALS
ROLE Principal investigator
ID USA2013-0003 (2014-2016)

 

NAME ECOS-CONICYT – Cooperation grant Chile-France
TITLE Functional study of the IRE1a interactome in cell migration and cancer
ROLE Principal investigator
ID C13S02 (2014-2016)

 

NAME Chilean government funding agency FONDEF.
TITLE UPRplus: A novel gene therapy to treat Parkinson´s disease.
ROLE Principal investigator.
ID D11I1007 (2012-2015)

 

NAME Frick Foundation, Switzerland
TITLE Defining the contribution of ER proteostasis disturbances to ALS
ROLE Associate investigator
ID 20014-15 (2015-2016)

 

NAME Ring Initiative, Chile
TITLE Neuronal network initiative: Understanding selective neuronal vulnerability in neurodegenerative diseases
ROLE Associate investigator
ID ACT1109 (2013-2015)

 

NAME FONDEQUIP
TITLE Cellomics: An automatized platform for high throughput microscopy with biotechnological potential
ROLE Principal investigator
ID EQM120164 (2012)

 

NAME Chilean government funding agency FONDECYT
TITLE Defining the contribution of the disulfide isomerase ERp57 to the pathogenesis of Prion-related disorders
ROLE Principal investigator
ID FONDECYT 1100176 (2010-2014). Project ranked number one in the study section

 

NAME FONDECYT Chile
TITLE The tumor suppressor activity of Caveolin 1 is associated with an inhibition of the UPR
ROLE Co-investigator
ID FONCECYT 1090071 (2009-1013)

 

NAME Chilean government funding agency FONDECYT
TITLE Regulation of neuronal apoptosis by Abl in Alzheimer’s disease
ROLE Co-investigator
ID 1080221 (2008-2012)

 

NAME FONDAP (Program grant)
TITLE FONDAP Center for Molecular Studies of the Cell (CEMC)
ROLE Principal investigator
ID FONDAP 15010006 (2007-2012)

 

NAME Chilean government, Millennium Scientific Initiative (Program grant)
TITLE Millennium Nucleus for Neural Morphogenesis (NEMO)
ROLE Associate investigator
ID Nucleo Milenio # P07-048-F (2009-2011)

 

NAME Chilean government funding agency FONDECYT
TITLE Regulation of the Unfolded Protein Response (UPR) by the stress sensor IRE1? and its role in neurological disorders
ROLE Principal investigator and project manager
ID 1070444 (2007-2010). Project Ranked number one in the study section

 

INTERNATIONAL

 

NAME ALS Therapy Alliance, USA
TITLE Gene therapy to alleviate ER proteostasis alterations in ALS
ROLE Principal Investigator
2014-F-059 (2015-2017)

 

NAME The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE Targeting the ER stress sensor PERK for the treatment of Parkinson´s disease
ROLE Principal Investigator
ID 9277. Target Validation grant (2014-2016)

 

NAME Alzheimer’s Association, USA
TITLE Defining the role of the Unfolded Protein Response in Alzheimer’s Disease
ROLE Principal Investigator
ID 2012-2014

 

NAME Muscular Dystrophy Association, USA
TITLE A role of ER stress in wild-type SOD1 misfolding: A model for sALS?
ROLE Principal Investigator and project manager
ID MDA218655 (2012-2015)

 

NAME ALS Therapy Alliance, USA.
TITLE Defining the function of potein Disulfide Isomerases in ALS
ROLE Principal Investigator and project manager (2012-2015)

 

NAME The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE Targeting the unfolded protein response (UPR) transcription factor XBP1 to alleviate neurodegeneration triggered by alpha-synuclein
ROLE Principal Investigator
ID Target Validation grant (2012-2013)

 

NAME Christopher Reeve Spinal Cord Injury and Paralysis Foundation, USA
TITLE targeting ER stress in Spinal Cord Injury
ROLE Principal Investigator
ID 2015

 

NAME North American Spine Society (NASS), USA
TITLE Defining the role of the endoplasmic reticulum (ER) stress and the UPR in spinal cord injury
ROLE Principal Investigator
ID Research grant (2011-2012)

 

NAME Alzheimer’s Association, USA
TITLE Defining the role of the Unfolded Protein Response in Alzheimer s Disease
ROLE Principal Investigator
ID NIRG-10-173294 (2010-2012)

 

NAME The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE Targeting the Unfolded Protein Response (UPR) transcription factor XBP-1 to treat Parkinson’s
ROLE Principal Investigator
ID Target Validation grant (2010-2011)

 

NAME GENZYME, USA
TITLE Targeting BECLIN-1 to modulate autophagy mediated degradation of mutant SOD1 and other disease related misfolded proteins
ROLE Principal investigator. SOURE: Sponsored Research Agreement (2010-2011)

 

NAME ICGEB, International Center for Genetic Engineering and Biotechnology. Italy
TITLE Role of the Unfolded Protein Response (UPR) in tumor suppression by caveolin-1
ROLE Principal Investigator
ID CRP/CHI08-03 (2009-2011)

 

NAME CHDI Foundation, Inc, Research Grant, USA
TITLE Defining the role of the Unfolded Protein Response in Huntington’s disease in vivo
ROLE Principal Investigator (2008-2010)

 

NAME Muscular Dystrophy Association, USA
TITLE Targeting Autophagy for the removal of mutant SOD1 in ALS
ROLE Principal Investigator and project manager
ID MDA10036 (2008-2010)

 

NAME The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE A role of the UPR in Parkinson’s disease
ROLE Principal Investigator
ID 2008-2009

 

NAME National Parkinson Foundation, USA
TITLE Defining the contribution of endoplasmic reticulum (ER) stress in Parkinson’s disease
ROLE Principal Investigator and project manager
ID 2008-2009

 

NAME GENZYME, USA
TITLE Targeting Autophagy for the treatment of Protein Conformational Disorders affecting the nervous system
ROLE Principal investigator
ID 2008-2009

 

NAME High Q Foundation, discovery initiative, USA
TITLE A role of Endoplasmic Reticulum Stress in Huntington’s Disease
ROLE Principal Investigator and project manager
ID 2007-2008

 

NAME Damon Runyon Cancer Research Foundation
TITLE BCL-2 regulation of the endoplasmic reticulum stress response and apoptosis
ROLE Principal investigator
ID 2004-2007

 

POSTDOC FELLOW

 

NAME Chilean Government Funding agency FONDECYT.
TITLE Modulation of mitochondrial metabolism by the ER stress sensor IRE1: Dual impact in calcium signaling and bioenergetics.
ROLE Patrocinante
PI Amado Carreras Sureda
ID 3150113 (2014-2017)

 

NAME Chilean Government Funding agency FONDECYT.
TITLE Role of insulin growth factor 2 (IGF2) in the neuroprotection observed by XBP1 deficiency
ROLE Patrocinante
PI Paula Garcia Huerta
ID 3150097 (2014-2017)

 

NAME Chilean government funding agency FONDECYT
TITLE Role of the Integrated Stress Response in the survival of dopaminergic neurons in pre-clinical models Parkinson’s Disease
ROLE Principal Investigator
PI María Gabriela Mercado
ID 11140738 (2014-2017)

 

NAME Chilean Government Funding agency FONDECYT
TITLE Regulation of an AD-like process by the UPR transcription factor XBP1 in vivo
ROLE Supervisor
PI Claudia Duran
ID 3140466 (2013-2016)

 

NAME Chilean Government Funding agency FONDECYT
TITLE Functional role of the UPR in the physiology of the nervous system
ROLE Supervisor
PI Pablo Mardones
ID 3140388 (2013-2016)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE FINE TUNING OF THE UPR: functional analysis of the IRE1 interactome
ROLE Collaborator as Supervisor
PI Diego Rojas-Rivera
ID 3130365 (2012-2015)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE Defining Mechanisms and the Role of Aggregation of Wild-type Superoxide Dismutase 1 (SOD1) in Amyotrophic Lateral Sclerosis
ROLE Supervisor
PI Danilo Medinas
ID 3130351 (2011-2014)

 

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE The role of ER-resident protein disulfide isomerases (PDIs) in the misfolding and neurotoxicity of mutant PrP and SOD1
ROLE Supervisor
PI Ute Woehlbier
ID 3110067 (2011-2013)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE Assessment of the combinatorial role of loss-of-function of the endogenous prion protein and gain-of-toxic activity of the misfolded PrPE200K mutant protein in a zebrafish model of Creutzfeldt-Jakob disease
ROLE Supervisor
PI Nestor Guerrero
ID 3130757 (2012-2015)

 

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE Alpha-Synuclein internalization and ER stress response
ROLE Supervisor
PI Gabriela Mercado
ID 3120146 (2011-2014)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE Defining the contribution of the Unfolded Protein Response (UPR) in the pathogenicity of mutant Huntingtin
ROLE Supervisor
PI Rene Vidal
ID FONCECYT 3100039 (2009-2012)

 

NAME CONICYT Insertion into the Academy fellowship, Chile
TITLE Defining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS
ROLE Supervisor
PI Soledad Matus
ID 2010-2012

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE Induction of autophagy pathway protects against motoneuron degeneration in Amyotrophic Lateral Sclerosis induced by mutant SOD1 aggregation
ROLE Supervisor
PI Karen Castillo
ID FONCECYT #3100112 (2009-2012)

 

NAME ALS Association (ALSA), Post-doctoral grant. USA
TITLE Defining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS
ROLE Supervisor
PI Soledad Matus
ID ALSA 1829 (2009-2011)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE GRINA, a new BI-1 homologue, regulates endoplasmic reticulum (ER) stress responses
ROLE Supervisor
PI Diego Rodriguez
ID FONCECYT 3100033 (2009-2011)

 

NAME FONDECYT, Post-doctoral grant. Chile
TITLE The role of the Unfolded Protein Response on neurodegeneration in Amyotrophic Lateral Sclerosis
ROLE Supervisor
PI Soledad Matus
ID FONCECYT 3085017 (2008-2010)