Accelerating Discovery

CURRENT RESEARCH SUPPORT

NATIONAL


NAMEFONDAP (Program grant)
TITLEFONDAP Geroscience Center for Brain Health and Metabolism.
ROLEAssociate Investigator
ID15150012 2011-2020


NAMEChilean Government Funding agency FONDECYT.
TITLEDefining the Contribution of ERp57 mutants to the Pathogenesis of Amyotrophic Lateral Sclerosis.
ROLEPrincipal Investigator
PIDanilo Bilches Medinas
IDFONDECYT 11150579. 2015-2018


NAMEChilean government funding agency FONDECYT.
TITLERole of the Integrated Stress Response in the survival of dopaminergic neurons in pre-clinical models Parkinson’s Disease.
ROLEPrincipal Investigator
PIMaría Gabriela Mercado
IDFONDECYT 11140738. 2014-2016


NAMEChilean government funding agency FONDECYT.
TITLEThe UPRosome: novel regulatory checkpoints and physiological outputs.
ROLEPrincipal Investigator.
IDFONDECYT 1140549 2014-2017


NAMEFundacion COPEC-UC
TITLEIdentification of neuroprotective compounds from chilean endogenous plants
ROLEPrincipal Investigator
IDProyecto COPEC-UC 2013.R.40 2014-2016


NAMEChilean government, Millennium Scientific Initiative (Program grant).
TITLEBiomedical Neuroscience Institute (BNI).
ROLEDeputy Director.
IDP09-015-F 2011-2021


NAMECONICYT-Cooperation grant Chile-EEUU
TITLEGene therapy strategy to target the unfolded protein response in ALS.
ROLEPrincipal Investigator
IDUSA2013-0003. 2014-2016


NAMEECOS-CONICYT - Cooperation grant Chile-France
TITLEFunctional study of the IRE1a interactome in cell migration and cancer.
ROLEPrincipal Investigator
IDC13S02. 2014-2016




INTERNATIONAL


NAMEOffice of Naval Research- Global (ONR-G). 

TITLEA novel function of the Unfolded Protein Response (UPR) in learning and memory.
ROLEPrincipal Investigator
IDN62909-16-1-2003. 2015-2017


NAMEALS Therapy Alliance, USA.
TITLEGene therapy to alleviate ER proteostasis alterations in ALS.
ROLEPrincipal Investigator
ID2014-F-059. 2015-2017


NAMEMuscular Dystrophy Association, USA.
TITLETargeting the endoplasmic reticulum (ER) stress sensor IRE1 to treat ALS
ROLEPrincipal Investigator
ID382453 2016-2019


NAMECDMRP ALS Research Program (ALSRP) Therapeutic Idea Award, USA
TITLETargeting the ER Stress Sensor IRE1 to Treat ALS
ROLEPrincipal Investigator
IDAL150111. 2016-2017


NAMEThe Frick Foundation, Switzerland
TITLEDefining the contribution of ER proteostasis disturbances to ALS
ROLEPrincipal Investigator
ID2015-2017


NAMEThe Michael J. Fox Foundation for Parkinson's Research, USA
TITLETargeting the ER stress sensor PERK for the treatment of Parkinson´s disease
ROLEPrincipal Investigator
IDTarget Validation grant. 2014-2015




POSTDOC FELLOW


NAMEChilean Government Funding agency FONDECYT.
TITLEModulation of mitochondrial metabolism by the ER stress sensor IRE1: Dual impact in calcium signaling and bioenergetics.
ROLEPatrocinante
PIAmado Carreras Sureda
IDFONDECYT 3150113


NAMEChilean Government Funding agency FONDECYT.
TITLERole of ER stress on the cell autonomous or non-autonomous effect trigerred by Wallerian degeneration
ROLECollaborator as Supervisor
PIGabriela Martinez
IDFONDECYT 3150637


NAMEChilean Government Funding agency FONDECYT.
TITLERole of insulin growth factor 2 (IGF2) in the neuroprotection observed by XBP1 deficiency
ROLEPatrocinante
PIPaula Garcia Huerta
IDFONDECYT 3150097


NAMEChilean Government Funding agency FONDECYT.
TITLEDefining the contribution of the UPR stress sensor IRE1 in tumor and stromal cells to the development of brain cancer.
ROLECollaborator as Supervisor
PIHery Urra Zúñiga (Co-advisor Andres Couve)
IDFONDECYT 3160461. 2016-2018


NAMEChilean Government Funding agency FONDECYT.
TITLERegulation of an AD-like process by the UPR transcription factor XBP1 in vivo
ROLESupervisor
PIClaudia Duran
IDFONCECYT 3140466. 2013-2016


NAMEChilean Government Funding agency FONDECYT.
TITLEFunctional role of the UPR in the physiology of the nervous system.
ROLESupervisor
PIPablo Mardones
IDFONCECYT 3140388. 2013-2016




PAST RESEARCH SUPPORT

NATIONAL


NAMEChilean government funding agency FONDEF.
TITLEUPRplus: A novel gene therapy to treat Parkinson´s disease.
ROLEPrincipal investigator.
IDD11I1007. 2013-2015.


NAMERing Initiative, Chile.
TITLENeuronal network initiative: Understanding selective neuronal vulnerability in neurodegenerative diseases.
ROLEAssociate investigator. ID: ACT1109
IDACT1109. 2013-2015.


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEAlpha-Synuclein internalization and ER stress response
ROLESupervisor
PIGabriela Mercado.
IDFONCECYT 3120146. 2011-2014.


NAMEFONDEQUIP
TITLECellomics: An automatized platform for high throughput microscopy with biotechnological potential.
ROLEPrincipal investigator.
IDEQM120164. 2012


NAMEChilean government funding agency FONDECYT.
TITLEDefining the contribution of the disulfide isomerase ERp57 to the pathogenesis of Prion-related disorders.
ROLEPrincipal investigator.
IDFONDECYT 1100176. 2010-2014.


NAMEFONDECYT, Post-doctoral grant. Chile 

TITLEThe role of ER-resident protein disulfide isomerases (PDIs) in the misfolding and neurotoxicity of mutant PrP and SOD1. 

ROLESupervisor
PIUte Woehlbier.
IDFONDECYT 3110067. 2011-2013.


NAMEFONDECYT Chile
TITLEThe tumor suppressor activity of Caveolin 1 is associated with an inhibition of the UPR
ROLECo-investigator.
IDFONCECYT 1090071. 2009-1013.


NAMEChilean government funding agency FONDECYT.
TITLERegulation of neuronal apoptosis by Abl in Alzheimer's disease.
ROLECo- investigator.
IDFONDECYT 1080221. 2008-2012.


NAMEFONDAP (Program grant)
TITLEFONDAP Center for Molecular Studies of the Cell (CEMC)
ROLEAssociate investigator.
IDFONDAP 15010006. 2007-2012.


NAMECONICYT Insertion into the Academy fellowship, Chile.
TITLEDefining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS.
ROLESupervisor
PISoledad Matus.
ID2010-2012


NAMEChilean government, Millennium Scientific Initiative (Program grant).
TITLEMillennium Nucleus for Neural Morphogenesis (NEMO).
ROLEAssociate investigator.
IDNucleo Milenio # P07-048-F. 2009-2011.


NAMEChilean government funding agency FONDECYT.
TITLERegulation of the Unfolded Protein Response (UPR) by the stress sensor IRE1α and its role in neurological disorders.
ROLEPrincipal investigator and project manager.
IDFONDECYT 1070444. Project Ranked number one in the study section. 2007-2010.




INTERNATIONAL


NAMEAlzheimer’s Association, USA
TITLEDefining the role of the Unfolded Protein Response in Alzheimer's Disease
ROLEPrincipal Investigator.
ID2012-2014.


NAMEMuscular Dystrophy Association, USA.
TITLEA role of ER stress in wild-type SOD1 misfolding: A model for sALS?
ROLEPrincipal Investigator and project manager.
IDMDA218655. 2012-2015


NAMEALS Therapy Alliance, USA.
TITLEDefining the function of potein Disulfide Isomerases in ALS
ROLEPrincipal Investigator and project manager. 2012-2015


NAMEThe Michael J. Fox Foundation for Parkinson's Research, USA
TITLETargeting the unfolded protein response (UPR) transcription factor XBP1 to alleviate neurodegeneration triggered by alpha-synuclein
ROLEPrincipal Investigator.
IDTarget Validation grant. 2012-2013.


NAMEChristopher Reeve Spinal Cord Injury and Paralysis Foundation, USA
TITLEtargeting ER stress in Spinal Cord Injury
ROLEPrincipal Investigator.
ID2013.


NAMENorth American Spine Society (NASS), USA
TITLEDefining the role of the endoplasmic reticulum (ER) stress and the UPR in spinal cord injury
ROLEPrincipal Investigator.
IDResearch grant. 2011-2012.


NAMEAlzheimer’s Association, USA
TITLEDefining the role of the Unfolded Protein Response in Alzheimer s Disease
ROLEPrincipal Investigator.
IDNIRG-10-173294. 2010-2012.


NAMEThe Michael J. Fox Foundation for Parkinson's Research, USA
TITLETargeting the Unfolded Protein Response (UPR) transcription factor XBP-1 to treat Parkinson’s
ROLEPrincipal Investigator.
IDTarget Validation grant. 2010-2011.


NAMEGENZYME, USA.
TITLETargeting BECLIN-1 to modulate autophagy mediated degradation of mutant SOD1 and other disease related misfolded proteins.
ROLEPrincipal investigator. SOURE: Sponsored Research Agreement. 2010-2011.


NAMEICGEB, International Center for Genetic Engineering and Biotechnology. Italy.
TITLERole of the Unfolded Protein Response (UPR) in tumor suppression by caveolin-1.
ROLEPrincipal Investigator.
IDCRP/CHI08-03. 2009-2011.


NAMECHDI Foundation, Inc, Research Grant, USA
TITLEDefining the role of the Unfolded Protein Response in Huntington's disease in vivo.
ROLEPrincipal Investigator. 2008-2010.


NAMEMuscular Dystrophy Association, USA.
TITLETargeting Autophagy for the removal of mutant SOD1 in ALS.
ROLEPrincipal Investigator and project manager.
IDMDA10036. 2008-2010.


NAMEThe Michael J. Fox Foundation for Parkinson's Research, USA
TITLEA role of the UPR in Parkinson's disease
ROLEPrincipal Investigator and project manager.
ID2008-2009.


NAMENational Parkinson Foundation, USA
TITLEDefining the contribution of endoplasmic reticulum (ER) stress in Parkinson's disease.
ROLEPrincipal Investigator and project manager.
ID2008-2009.


NAMEGENZYME, USA.
TITLETargeting Autophagy for the treatment of Protein Conformational Disorders affecting the nervous system.
ROLEPrincipal investigator.
ID2008-2009.


NAMEHigh Q Foundation, discovery initiative, USA
TITLEA role of Endoplasmic Reticulum Stress in Huntington’s Disease.
ROLEPrincipal Investigator and project manager.
ID2007-2008.


NAMEDamon Runyon Cancer Research Foundation
TITLEBCL-2 regulation of the endoplasmic reticulum stress response and apoptosis.
ROLEPrincipal investigator.
ID2004-2007




POSTDOC FELLOW


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEFINE TUNING OF THE UPR: functional analysis of the IRE1 interactome
ROLECollaborator as Supervisor
PIDiego Rojas-Rivera
IDFONCECYT 3130365 2012-2015


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEDefining Mechanisms and the Role of Aggregation of Wild-type Superoxide Dismutase 1 (SOD1) in Amyotrophic Lateral Sclerosis
ROLESupervisor
PIDanilo Medinas
IDFONCECYT 3130351 2011-2014


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEAssessment of the combinatorial role of loss-of-function of the endogenous prion protein and gain-of-toxic activity of the misfolded PrPE200K mutant protein in a zebrafish model of Creutzfeldt-Jakob disease
ROLESupervisor
PINestor Guerrero
IDFONCECYT 3130757 2012-2015


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEDefining the contribution of the Unfolded Protein Response (UPR) in the pathogenicity of mutant Huntingtin
ROLESupervisor
PIRene Vidal.
IDFONCECYT 3100039. 2009-2012.


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEInduction of autophagy pathway protects against motoneuron degeneration in Amyotrophic Lateral Sclerosis induced by mutant SOD1 aggregation
ROLESupervisor
PIKaren Castillo.
IDFONCECYT #3100112. 2009-2012.


NAMEALS Association (ALSA), Post-doctoral grant. USA
TITLEDefining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS.
ROLESupervisor
PISoledad Matus.
IDALSA 1829. 2009-2011.


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEGRINA, a new BI-1 homologue, regulates endoplasmic reticulum (ER) stress responses
ROLESupervisor
PIDiego Rodriguez.
IDFONCECYT 3100033. 2009-2011.


NAMEFONDECYT, Post-doctoral grant. Chile
TITLEThe role of the Unfolded Protein Response on neurodegeneration in Amyotrophic Lateral Sclerosis
ROLESupervisor
PISoledad Matus.
IDFONCECYT 3085017. 2008-1010.